Intuitive Fasting with Dr. Will Cole [Episode #561]
Ā
This weekās topic is: Intuitive Fasting with Dr. Will Cole
I am so excited to have my very special guest, Dr. Will Cole, who is a bestselling author, health advisor and functional-medicine expert and the host of The Art of Being Well podcast. Listen in as Will shares the difference between intuitive fasting and intermittent fasting, how he personally fasts, the benefits of intuitive fasting and how to look and feel your best.
- If fasting alone helps with inflammationā¦
- Autoimmune diseases and inflammationā¦
- The difference between intuitive fasting and intermittent fastingā¦
- Intuitive fasting and the four-week cycle ā¦
- Fertility issues into conceptionā¦
- Will shares how he personally fasts and tools to help people with cravingsā¦
- The benefits of intuitive fasting to feel and look your bestā¦

About Dr. Will Cole
Dr. Will Cole is a leading functional medicine expert who consults people around the world via webcam. Named one of the top 50 functional-medicine and integrative doctors in the nation, Dr.Cole specializes in clinically investigating underlying factors of chronic disease and customizing a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. He is the bestselling author and the host of the new podcast, The Art of Being Well.
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Dr. Coleās Interview
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Transcript:
Note: The following is the output of transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate. This is due to inaudible passages or transcription errors. It is posted as an aid, but should not be treated as an authoritative record.
Kimberly: Hey Beauties, welcome back to our Monday Interview podcast. Iām very excited for our guest today, who is Dr. Will Cole. He was named as one of the top 50 functional medicine and integrative doctors in the nation. Heās also a bestselling author and he has a new book out called, Intuitive Fasting. We talked about so many different aspects today, of inflammation and getting back into balance. And I have to say, that this podcast was very information packed, and I think youāre going to enjoy it very much.
Fan of the Week
Kimberly: But before we get into our show today, I just want to give a quick shout-out to our fan of the week and his or her name is V-V-F-S and he or she writes, āAmazing shows. I look forward to listening to Kimberlyās podcast daily, always learning more is a gift. So grateful for these shows. Thank you, Kimberly.ā Well V-V-F-S, thank you so much for being our fan of the week. Thank you so much for your review. I send you such a big, warm virtual hug. It means so much to me. Thank you. Thank you. Thank you from the bottom of my heart.
Leave a Review on iTunes
Kimberly: And Beauties, for your chance to also be shouted-out as our fan of the week, please just take a moment or two out of your day and head over to iTunes, leave us a review over on iTunes and itās just a great way to support the show energetically. And while youāre over there, please be sure to also subscribe to our show and that way you donāt miss out on any of these interviews or solo casts or our Thursday, Q&A Community show, as well. All right. All that being said, letās get right into our interview today with Dr. Will Cole.
Interview with Dr. Will Cole on Intuitive Fasting
Kimberly: Will, itās so nice to talk to you today .
Will Cole: Thank you.
Why the focus on inflammation
Kimberly: I have your new book here in front of me. I wonder how you even got into focusing on inflammation in the first place. Does it have
Will Cole: Yeah, I started one of the first functional medicine telehealth centers over a decade ago. Iāve been consulting people via webcam, 50 plus hours a week. You see so many different manifestations of chronic inflammation. The concept of inflammation is something that I see on an hourly basis.
Will Cole: Of course, itās going to be in the things that I write about, because I see the power of the human health. The power of human resilience, when you give the body what it needs, or give it a break sometimes, just start to find homeostasis, to find balance again. Yeah, itās definitely ⦠Intuitive Fasting, my newest book, inflammation is throughout that book as well, for the same reason. Iām fasting, and flexible intermittent fasting specifically, is a great modulator of lowering inflammation levels. Yeah, without a doubt.
If fasting alone helps with inflammation
Kimberly: Fasting is a concept thatās been used in yogic culture. Itās an ancient practice thatās been around. Would you say that ⦠Is it fasting alone that can really make a difference in inflammation or does it have to be coupled with of course some lifestyle shifts as well?
Will Cole: Well, I mean, if you look at the scientific literature, thereās many studies that show, and this was needed, right? To be done in the scientific journals to see does fasting stand on its own or is the benefits from changing the foods that you eat? Or does it changed from decreasing calories? Whatās the actual mechanism at play here? There have been studies done to show the fasting by itself is a modulator of human biochemistry in a beneficial way at lowering inflammation levels or increasing healing pathways. But there are other studies that show if people donāt ⦠If they do just try to fast their way out of a poor diet and donāt change most of the eating, itās going to work for some people and not work for everybody.
Will Cole: Thatās what I see clinically too, is that, yeah, you may get lucky. If you have good resilience and you still eat like crap and you do some flexible intermittent fasting time restricted feeding, you may see some positive changes, and I definitely have seen that clinically, but itās definitely not what I would advocate for people for long term health. I donāt advocate fasting the way I report. Diet food is such a powerful medicine and using nutrition to improve your health. But you can amplify that with some flexible intermittent fasting, like you said. Humans have done it for thousands of years. Itās just reminding people this is actually a part of humanity for a long time.
Kimberly: Will, before we get into the fasting, which I think is really fascinating and I think people want to know more information about how exactly to do it, can we talk about inflammation for a little bit more?
Will Cole: Sure.
Kimberly: Because we talked about food, thereās sugar, thereās chemicals in the food supply, but I hear so many people saying autoimmune is crazy hormonal issues. Why is inflammation now this level?
Will Cole: This is something I talked about at length with my patients, but obviously throughout Inflammation Spectrum and into the fasting. Thereās this evolutionary mismatches, epigenetic-genetic chasm between our genetics, which hasnāt changed in 10,000 years, and the world around us, which has changed very dramatically in a very short period of time. When you putting that into context with the totality of human history, I mean, the food supply has changed very quickly, our air supply, water supply, the hybridization, the genetic modification, soil depletion, chronic stressors, technology, all of these things come with amazing convenience.
Will Cole: I mean, they are good aspects of modernity. Of course, weāre talking to people around the world right now. I donāt think we have to demonize the entirety of modernity. But I think we have to look at some of the price that we paid in through this process. Is there a way to have better checks and balances and a healthier relationship with modernity? Or we donāt have to pick either or it can be both? I think that when you look at this genetic-epigenetic mismatch, our DNA is living in this brave new world. These genetic predispositions have always been there, but theyāre being awoken like never before in human history because of the onslaught of these environmental epigenetic triggers, food being a part of that, but not everything.
Will Cole: That is why weāre seeing this epidemic rise of chronic inflammatory issues, which chronic inflammation is this common link, this commonality, between just about every health problem under the sun, when youāre looking at things like metabolic issues, Type 2 diabetes, cancers, autoimmune conditions, even things that impact the brain. I mean, people, theyād like to separate mental health from physical health, but mental health is physical health. Our brain is part of our body, and thereās research looking at inflammation thatās called the cytokine model of cognitive function. How is inflammation impacts our brains work? How does inflammation impact mental health?
Will Cole: This neuroinflammatory is brain inflammation component to anxiety and depression, fatigue, brain fog, ADD, ADHD, autism. All the things I just mentioned, sadly is the majority of the human race to some degree. But inflammation exists on a spectrum. By the time someone is diagnosed with a chronic health problem, whether that be diabetes or an autoimmune condition, something like this, research estimates itās about four to 10 years prior to that diagnosis is when things were brewing on this inflammation spectrum.
Kimberly: Wow.
Will Cole: No matter where youāre at on this, inflammation continuum, and what can you do today to start to calm things down? Because inflammation is not inherently bad, itās a product of our immune system. Inflammation is good when you want it to fight viruses and kill off bacteria and heal wounds and be a protector. The problem is if inflammation is too high for too long, itās a breaking of the Goldilocks principle, right? You donāt want inflammation too high, you donāt want inflammation too low. You want to just right at the right time. The problem is that weāre breaking this Goldilocks principle because of this evolutionary mismatch, and that applies to everything else in the body too.
Will Cole: Gut microbiome, we donāt want bacterial overgrowth, but we donāt want to deficient. Or hormones, we donāt want hormone excess and dominance, but we donāt want deficiencies of it either. Inflammation is the same thing. We want it just right at the right time. Thatās a major part of my work, is to really give people tools to calm this inflammation levels down and then ask the question clinically, and for the person to start asking this question, whatās causing the inflammation in the first place? Itās multifactorial. Foods are a part of it, but itās certainly only a piece of the puzzle.
Autoimmune diseases and inflammation
Kimberly: Well, letās say ⦠Letās talk about autoimmune, for example, because I feel that, especially in the past three years and Iām sure youāve seen maybe five years, two years, whatever it is, thereās just been so many people that have come out, and maybe itās nonspecific or maybe it gets ⦠Or some people say, āItās Lyme disease.ā Whatever it is, but thereās been this huge rise. In your opinion, how much of autoimmune diseases, how much of it is caused by inflammation? For instance, if they follow your program and theyāre able to really focus on the inflammation piece. I know itās hard to say specifically. But what would you estimate? How would that help alleviate suffering for those with autoimmune?
Will Cole: Yeah. I mean, we break that word down autoimmune, itās when the immune system turns against itself. Inflammation is a product of the immune system. There is an inflammatory component to every autoimmune condition. Itās not something that is up for ⦠Itās the pathogenesis of the actual disease. Itās when the immune system loses recognition of self. The immune system has this beautiful ability to normally, under normal circumstances, to see an invader like a virus or bacteria, a pathogen and attack it. It tags it with an antibody and then attacks it. Well, autoimmunity is when the immune system loses recognition of self and thereās a phenomenon called molecular mimicry.
Will Cole: Itās sort of the case of mistaken identity. When the immune system thinks that the thyroid, or thinks that the joint, or thinks that the gut, or thinks that the brain, the nervous system, is a virus. Then it tags it with an antibody and attacks it as if it was an invader. The immune system is losing recognition of self. Thereās so many. I mean, thatās so symbolic. I think of a lot of whatās going on in humanity, we are losing recognition of self. How many people have turned against themselves on a mental emotional level and a spiritual level? Thatās whatās happening in many peopleās bodies on a physical level too.
Will Cole: If you look even on another symbolic level, look at whatās going on globally, the amount of climate change and global warming and ⦠We have individual physiological climate change going on in the form of chronic inflammation. As above, so below, and weāre part of nature. Whatās happening globally because of what weāve done to planet earth is also happening to our body in the form of chronic inflammation, that breaking up that Goldilocks principle. Itās definitely a problem. But all of these things are inflammation. But the body is amazingly resilient, and we can calm that down.
Will Cole: Researchers estimate that genetics play a part of autoimmunity for most people. Itās about a third genetics and two thirds epigenetics. Instead of thinking genetics is nothing, itās something, but why is it being triggered? Why is it being awoken? Thatās the issue, is why is there 50 million Americans happening autoimmune disease now? Why is it growing by leaps and bounds when our genes havenāt changed in 10,000 years? Better diagnostics is part of it, but it doesnāt explain the full breadth of whatās going on today.
Autoimmune diseases, inflammation and remission
Kimberly: What is it that once someone has autoimmune, can they eradicate it or is it only to your word, calming it down? I have a friend who has Crohnās and she hasnāt had an outbreak in 10 years, and now all of a sudden sheās going ⦠Her body is just completely breaking down. Itās been 10 years. Is it actually possible to say, āIām cured of autoimmune,ā or is it below the surface and weāre just trying to control it?
Will Cole: Yeah. The clinical objective for most people in full-blown autoimmune diseases to put it into remission. That would be the correct understanding of whatās going on. Because thereās really no research to show youāre going to be cured of it or completely gone. But look, thereās a larger continuum here. On one end of the autoimmune inflammation spectrum is silent autoimmunity. Meaning if you ran labs, youād see positive antibodies made positive
Will Cole: But many people are in this stage two of autoimmune reactivity, meaning they are symptomatic. They do have symptoms, labs show that thereās autoimmune components to their case, their doctors often even say, āWell, it looks autoimmune,ā they have a family history of autoimmunity, et cetera, but theyāre really not given many tools and theyāre labeled with things typically like fibromyalgia or chronic fatigue syndrome or IBS, or these inflammatory symptoms. But what can they do today to start to arrest and calm and to have agency over their health? Whether youāre in autoimmune reactivity or autoimmune disease, the goal is to calm down the severity and the frequency of these things. There are people that get radical remissions and they never have a flare up again. I mean-
Kimberly: Right.
Will Cole: But my clinical objective for most people that are diagnosed with an autoimmune disease, meaning that itās been about four to 10 years prior to that when things were brewing on this inflammation spectrum, is to put it into remission, to start to decrease the severity in their frequency of their flares, which takes time and certainly not a quick fix, but thatās the goal for people.
Kimberly: What is the link between inflammation and fertility? Itās something we talk about a lot in our community, and Iām sure you hear about it as well. Thereās so many women struggling to get pregnant, to
Will Cole: Wow. I mean, itās a major part. I mean, you look at our endocrine system and we have the brainās brilliant communication with our rest of our endocrine system. We have the hypothalamic pituitary, ovarian axis, statisticular axis, all of this stuff, and then thyroid is a major part of the hypothalamic pituitary thyroid axis. All of these things are constantly and dynamically flowing and communicating with each other and influencing each other too. Thereās many complex reasons why somebody could be having infertility. My job as a functional medicine practitioner is to try to get out of the way and do a comprehensive health history.
Will Cole: Really listen and hold space for this person to understand, āOkay, whatās the nuances of their case,ā because every case is different. But also through that process, determine what labs would be the most appropriate for them. Whatās going to give us the best data to find out whatās their pieces of the puzzle, because it typically isnāt just one thing. Itās normally is that confluence of factors, that perfect storm of variables that are giving rise to their symptoms or experiences like infertility. I am always looking at this dance between the gut-brain axis, I mean the connection between the gut and brain, and for the people to understand that your gut and brain are actually formed from the same fetal tissue.
Will Cole: So when babies are growing in their momās womb, their gut and brain are formed from that same tissue, and theyāre inextricably linked for the rest of our life through, whatās known as the gut-brain axis. The intestines, if you think about even resemble the brain, but 95% of serotonin is made in the gut, stored in the gut. Itās referred to as the second brain. But I see this is ⦠Your gut, itās also home to 75% of the immune system. When youāre dealing with inflammatory problems, which is the product of the immune system, you want to look at where the predominance of the immune system
Will Cole: Thereās a inflammatory component, but the guts not healthy. Thereās also a conversion issue of many hormones. I see a lot of times people that have low T3 levels, in part because of their gut not being healthy, their bodyās not activating T3, which is needed for proper fertility, and also too when the body is stressed out to the gut-brain axis. I donāt just mean mental emotional stress and trauma, which is a part of it too. But mental emotional trauma, but Iām talking about physiological trauma too, like underlying gut issues and chronic infections and the ripple effect of chronic inflammation throughout the body.
Will Cole: That stress, that sympathetic fight or flight, my bodyās always an overdrive physiologically and probably externally as well, that really shifts the body away from parasympathetic, which is resting digesting hormone balance. I see so many women that are cycling that are trying to get pregnant. You look at their estrogen levels, you look at the progesterone levels, you look at their testosterone levels, you look at their cortisol levels just because itās on the same test, all of their hormones, in addition to their thyroid, are all completely out of balance, in part because the amount of chronic inflammation and stress that their body is under.
Will Cole: Thatās not to say thatās the only reason for their infertility, but it definitely is a piece of the puzzle that needs to be addressed. What my experience is, is for a lot of women, when they start dealing with these upstream root issues and start untangling these inflammatory cascades, the body can start to chill out a bit and get into the more of the parasympathetic resting, digesting. Theyāre eating these nutrient dense nourishing foods to impart help with that and support that. It is an amazing thing when you give the body the time it needs and you go upstream and find out whatās causing the problem in the first place, things happen a lot more unimpededly and a lot more effortlessly over time. Yeah, inflammation is linked to many different types of inflammatory problems.
Kimberly: Will, while weāre talking about fertility, I think we focus so much on women, but obviously it affects men and their sperm and their testes.
Will Cole: Yeah, right. Letās not talk about women now. Oftentimes, youāre right. Itās absolutely. The guys are completely ⦠The guy typically is in such an inflammatory state and itās the low testosterone. Itās impacting sperm count and sperm health. Yeah, both sides need to be looked at.
How long before you can see benefits with intuitive fasting
Kimberly: Yes. Letās talk about your new book, Intuitive Fasting in general. Letās say someone has a particular health goal. Theyāre trying to get pregnant or theyāre just trying to feel better. They had some of the symptoms you talked about a lot, the fogginess and the runny nose and the bloating. I mean, I know this is such a ⦠Itās so hard to make a generalization. But letās say someone starts to pay attention to the inflammation in their lives, they start to want to reduce it, they start to do some of the fasting. How long have you seen in your clinical research with your patients, how long can you actually start to see benefits?
Will Cole: Wow. If weāre leaning into these aspects, I mean, this goes without saying, but everybodyās coming in at different points of their journey, right? I mean, thatās same with clinically. Iām meeting people that have been dealing with these things for 40 years and for
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