Intuitive Fasting with Dr. Will Cole [Episode #561]
This week’s topic is: Intuitive Fasting with Dr. Will Cole
I am so excited to have my very special guest, Dr. Will Cole, who is a bestselling author, health advisor and functional-medicine expert and the host of The Art of Being Well podcast. Listen in as Will shares the difference between intuitive fasting and intermittent fasting, how he personally fasts, the benefits of intuitive fasting and how to look and feel your best.
- If fasting alone helps with inflammation…
- Autoimmune diseases and inflammation…
- The difference between intuitive fasting and intermittent fasting…
- Intuitive fasting and the four-week cycle …
- Fertility issues into conception…
- Will shares how he personally fasts and tools to help people with cravings…
- The benefits of intuitive fasting to feel and look your best…

About Dr. Will Cole
Dr. Will Cole is a leading functional medicine expert who consults people around the world via webcam. Named one of the top 50 functional-medicine and integrative doctors in the nation, Dr.Cole specializes in clinically investigating underlying factors of chronic disease and customizing a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. He is the bestselling author and the host of the new podcast, The Art of Being Well.
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Dr. Cole’s Interview
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Transcript:
Note: The following is the output of transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate. This is due to inaudible passages or transcription errors. It is posted as an aid, but should not be treated as an authoritative record.
Kimberly: Hey Beauties, welcome back to our Monday Interview podcast. I’m very excited for our guest today, who is Dr. Will Cole. He was named as one of the top 50 functional medicine and integrative doctors in the nation. He’s also a bestselling author and he has a new book out called, Intuitive Fasting. We talked about so many different aspects today, of inflammation and getting back into balance. And I have to say, that this podcast was very information packed, and I think you’re going to enjoy it very much.
Fan of the Week
Kimberly: But before we get into our show today, I just want to give a quick shout-out to our fan of the week and his or her name is V-V-F-S and he or she writes, “Amazing shows. I look forward to listening to Kimberly’s podcast daily, always learning more is a gift. So grateful for these shows. Thank you, Kimberly.” Well V-V-F-S, thank you so much for being our fan of the week. Thank you so much for your review. I send you such a big, warm virtual hug. It means so much to me. Thank you. Thank you. Thank you from the bottom of my heart.
Leave a Review on iTunes
Kimberly: And Beauties, for your chance to also be shouted-out as our fan of the week, please just take a moment or two out of your day and head over to iTunes, leave us a review over on iTunes and it’s just a great way to support the show energetically. And while you’re over there, please be sure to also subscribe to our show and that way you don’t miss out on any of these interviews or solo casts or our Thursday, Q&A Community show, as well. All right. All that being said, let’s get right into our interview today with Dr. Will Cole.
Interview with Dr. Will Cole on Intuitive Fasting
Kimberly: Will, it’s so nice to talk to you today .
Will Cole: Thank you.
Why the focus on inflammation
Kimberly: I have your new book here in front of me. I wonder how you even got into focusing on inflammation in the first place. Does it have
Will Cole: Yeah, I started one of the first functional medicine telehealth centers over a decade ago. I’ve been consulting people via webcam, 50 plus hours a week. You see so many different manifestations of chronic inflammation. The concept of inflammation is something that I see on an hourly basis.
Will Cole: Of course, it’s going to be in the things that I write about, because I see the power of the human health. The power of human resilience, when you give the body what it needs, or give it a break sometimes, just start to find homeostasis, to find balance again. Yeah, it’s definitely … Intuitive Fasting, my newest book, inflammation is throughout that book as well, for the same reason. I’m fasting, and flexible intermittent fasting specifically, is a great modulator of lowering inflammation levels. Yeah, without a doubt.
If fasting alone helps with inflammation
Kimberly: Fasting is a concept that’s been used in yogic culture. It’s an ancient practice that’s been around. Would you say that … Is it fasting alone that can really make a difference in inflammation or does it have to be coupled with of course some lifestyle shifts as well?
Will Cole: Well, I mean, if you look at the scientific literature, there’s many studies that show, and this was needed, right? To be done in the scientific journals to see does fasting stand on its own or is the benefits from changing the foods that you eat? Or does it changed from decreasing calories? What’s the actual mechanism at play here? There have been studies done to show the fasting by itself is a modulator of human biochemistry in a beneficial way at lowering inflammation levels or increasing healing pathways. But there are other studies that show if people don’t … If they do just try to fast their way out of a poor diet and don’t change most of the eating, it’s going to work for some people and not work for everybody.
Will Cole: That’s what I see clinically too, is that, yeah, you may get lucky. If you have good resilience and you still eat like crap and you do some flexible intermittent fasting time restricted feeding, you may see some positive changes, and I definitely have seen that clinically, but it’s definitely not what I would advocate for people for long term health. I don’t advocate fasting the way I report. Diet food is such a powerful medicine and using nutrition to improve your health. But you can amplify that with some flexible intermittent fasting, like you said. Humans have done it for thousands of years. It’s just reminding people this is actually a part of humanity for a long time.
Kimberly: Will, before we get into the fasting, which I think is really fascinating and I think people want to know more information about how exactly to do it, can we talk about inflammation for a little bit more?
Will Cole: Sure.
Kimberly: Because we talked about food, there’s sugar, there’s chemicals in the food supply, but I hear so many people saying autoimmune is crazy hormonal issues. Why is inflammation now this level?
Will Cole: This is something I talked about at length with my patients, but obviously throughout Inflammation Spectrum and into the fasting. There’s this evolutionary mismatches, epigenetic-genetic chasm between our genetics, which hasn’t changed in 10,000 years, and the world around us, which has changed very dramatically in a very short period of time. When you putting that into context with the totality of human history, I mean, the food supply has changed very quickly, our air supply, water supply, the hybridization, the genetic modification, soil depletion, chronic stressors, technology, all of these things come with amazing convenience.
Will Cole: I mean, they are good aspects of modernity. Of course, we’re talking to people around the world right now. I don’t think we have to demonize the entirety of modernity. But I think we have to look at some of the price that we paid in through this process. Is there a way to have better checks and balances and a healthier relationship with modernity? Or we don’t have to pick either or it can be both? I think that when you look at this genetic-epigenetic mismatch, our DNA is living in this brave new world. These genetic predispositions have always been there, but they’re being awoken like never before in human history because of the onslaught of these environmental epigenetic triggers, food being a part of that, but not everything.
Will Cole: That is why we’re seeing this epidemic rise of chronic inflammatory issues, which chronic inflammation is this common link, this commonality, between just about every health problem under the sun, when you’re looking at things like metabolic issues, Type 2 diabetes, cancers, autoimmune conditions, even things that impact the brain. I mean, people, they’d like to separate mental health from physical health, but mental health is physical health. Our brain is part of our body, and there’s research looking at inflammation that’s called the cytokine model of cognitive function. How is inflammation impacts our brains work? How does inflammation impact mental health?
Will Cole: This neuroinflammatory is brain inflammation component to anxiety and depression, fatigue, brain fog, ADD, ADHD, autism. All the things I just mentioned, sadly is the majority of the human race to some degree. But inflammation exists on a spectrum. By the time someone is diagnosed with a chronic health problem, whether that be diabetes or an autoimmune condition, something like this, research estimates it’s about four to 10 years prior to that diagnosis is when things were brewing on this inflammation spectrum.
Kimberly: Wow.
Will Cole: No matter where you’re at on this, inflammation continuum, and what can you do today to start to calm things down? Because inflammation is not inherently bad, it’s a product of our immune system. Inflammation is good when you want it to fight viruses and kill off bacteria and heal wounds and be a protector. The problem is if inflammation is too high for too long, it’s a breaking of the Goldilocks principle, right? You don’t want inflammation too high, you don’t want inflammation too low. You want to just right at the right time. The problem is that we’re breaking this Goldilocks principle because of this evolutionary mismatch, and that applies to everything else in the body too.
Will Cole: Gut microbiome, we don’t want bacterial overgrowth, but we don’t want to deficient. Or hormones, we don’t want hormone excess and dominance, but we don’t want deficiencies of it either. Inflammation is the same thing. We want it just right at the right time. That’s a major part of my work, is to really give people tools to calm this inflammation levels down and then ask the question clinically, and for the person to start asking this question, what’s causing the inflammation in the first place? It’s multifactorial. Foods are a part of it, but it’s certainly only a piece of the puzzle.
Autoimmune diseases and inflammation
Kimberly: Well, let’s say … Let’s talk about autoimmune, for example, because I feel that, especially in the past three years and I’m sure you’ve seen maybe five years, two years, whatever it is, there’s just been so many people that have come out, and maybe it’s nonspecific or maybe it gets … Or some people say, “It’s Lyme disease.” Whatever it is, but there’s been this huge rise. In your opinion, how much of autoimmune diseases, how much of it is caused by inflammation? For instance, if they follow your program and they’re able to really focus on the inflammation piece. I know it’s hard to say specifically. But what would you estimate? How would that help alleviate suffering for those with autoimmune?
Will Cole: Yeah. I mean, we break that word down autoimmune, it’s when the immune system turns against itself. Inflammation is a product of the immune system. There is an inflammatory component to every autoimmune condition. It’s not something that is up for … It’s the pathogenesis of the actual disease. It’s when the immune system loses recognition of self. The immune system has this beautiful ability to normally, under normal circumstances, to see an invader like a virus or bacteria, a pathogen and attack it. It tags it with an antibody and then attacks it. Well, autoimmunity is when the immune system loses recognition of self and there’s a phenomenon called molecular mimicry.
Will Cole: It’s sort of the case of mistaken identity. When the immune system thinks that the thyroid, or thinks that the joint, or thinks that the gut, or thinks that the brain, the nervous system, is a virus. Then it tags it with an antibody and attacks it as if it was an invader. The immune system is losing recognition of self. There’s so many. I mean, that’s so symbolic. I think of a lot of what’s going on in humanity, we are losing recognition of self. How many people have turned against themselves on a mental emotional level and a spiritual level? That’s what’s happening in many people’s bodies on a physical level too.
Will Cole: If you look even on another symbolic level, look at what’s going on globally, the amount of climate change and global warming and … We have individual physiological climate change going on in the form of chronic inflammation. As above, so below, and we’re part of nature. What’s happening globally because of what we’ve done to planet earth is also happening to our body in the form of chronic inflammation, that breaking up that Goldilocks principle. It’s definitely a problem. But all of these things are inflammation. But the body is amazingly resilient, and we can calm that down.
Will Cole: Researchers estimate that genetics play a part of autoimmunity for most people. It’s about a third genetics and two thirds epigenetics. Instead of thinking genetics is nothing, it’s something, but why is it being triggered? Why is it being awoken? That’s the issue, is why is there 50 million Americans happening autoimmune disease now? Why is it growing by leaps and bounds when our genes haven’t changed in 10,000 years? Better diagnostics is part of it, but it doesn’t explain the full breadth of what’s going on today.
Autoimmune diseases, inflammation and remission
Kimberly: What is it that once someone has autoimmune, can they eradicate it or is it only to your word, calming it down? I have a friend who has Crohn’s and she hasn’t had an outbreak in 10 years, and now all of a sudden she’s going … Her body is just completely breaking down. It’s been 10 years. Is it actually possible to say, “I’m cured of autoimmune,” or is it below the surface and we’re just trying to control it?
Will Cole: Yeah. The clinical objective for most people in full-blown autoimmune diseases to put it into remission. That would be the correct understanding of what’s going on. Because there’s really no research to show you’re going to be cured of it or completely gone. But look, there’s a larger continuum here. On one end of the autoimmune inflammation spectrum is silent autoimmunity. Meaning if you ran labs, you’d see positive antibodies made positive
Will Cole: But many people are in this stage two of autoimmune reactivity, meaning they are symptomatic. They do have symptoms, labs show that there’s autoimmune components to their case, their doctors often even say, “Well, it looks autoimmune,” they have a family history of autoimmunity, et cetera, but they’re really not given many tools and they’re labeled with things typically like fibromyalgia or chronic fatigue syndrome or IBS, or these inflammatory symptoms. But what can they do today to start to arrest and calm and to have agency over their health? Whether you’re in autoimmune reactivity or autoimmune disease, the goal is to calm down the severity and the frequency of these things. There are people that get radical remissions and they never have a flare up again. I mean-
Kimberly: Right.
Will Cole: But my clinical objective for most people that are diagnosed with an autoimmune disease, meaning that it’s been about four to 10 years prior to that when things were brewing on this inflammation spectrum, is to put it into remission, to start to decrease the severity in their frequency of their flares, which takes time and certainly not a quick fix, but that’s the goal for people.
Kimberly: What is the link between inflammation and fertility? It’s something we talk about a lot in our community, and I’m sure you hear about it as well. There’s so many women struggling to get pregnant, to
Will Cole: Wow. I mean, it’s a major part. I mean, you look at our endocrine system and we have the brain’s brilliant communication with our rest of our endocrine system. We have the hypothalamic pituitary, ovarian axis, statisticular axis, all of this stuff, and then thyroid is a major part of the hypothalamic pituitary thyroid axis. All of these things are constantly and dynamically flowing and communicating with each other and influencing each other too. There’s many complex reasons why somebody could be having infertility. My job as a functional medicine practitioner is to try to get out of the way and do a comprehensive health history.
Will Cole: Really listen and hold space for this person to understand, “Okay, what’s the nuances of their case,” because every case is different. But also through that process, determine what labs would be the most appropriate for them. What’s going to give us the best data to find out what’s their pieces of the puzzle, because it typically isn’t just one thing. It’s normally is that confluence of factors, that perfect storm of variables that are giving rise to their symptoms or experiences like infertility. I am always looking at this dance between the gut-brain axis, I mean the connection between the gut and brain, and for the people to understand that your gut and brain are actually formed from the same fetal tissue.
Will Cole: So when babies are growing in their mom’s womb, their gut and brain are formed from that same tissue, and they’re inextricably linked for the rest of our life through, what’s known as the gut-brain axis. The intestines, if you think about even resemble the brain, but 95% of serotonin is made in the gut, stored in the gut. It’s referred to as the second brain. But I see this is … Your gut, it’s also home to 75% of the immune system. When you’re dealing with inflammatory problems, which is the product of the immune system, you want to look at where the predominance of the immune system
Will Cole: There’s a inflammatory component, but the guts not healthy. There’s also a conversion issue of many hormones. I see a lot of times people that have low T3 levels, in part because of their gut not being healthy, their body’s not activating T3, which is needed for proper fertility, and also too when the body is stressed out to the gut-brain axis. I don’t just mean mental emotional stress and trauma, which is a part of it too. But mental emotional trauma, but I’m talking about physiological trauma too, like underlying gut issues and chronic infections and the ripple effect of chronic inflammation throughout the body.
Will Cole: That stress, that sympathetic fight or flight, my body’s always an overdrive physiologically and probably externally as well, that really shifts the body away from parasympathetic, which is resting digesting hormone balance. I see so many women that are cycling that are trying to get pregnant. You look at their estrogen levels, you look at the progesterone levels, you look at their testosterone levels, you look at their cortisol levels just because it’s on the same test, all of their hormones, in addition to their thyroid, are all completely out of balance, in part because the amount of chronic inflammation and stress that their body is under.
Will Cole: That’s not to say that’s the only reason for their infertility, but it definitely is a piece of the puzzle that needs to be addressed. What my experience is, is for a lot of women, when they start dealing with these upstream root issues and start untangling these inflammatory cascades, the body can start to chill out a bit and get into the more of the parasympathetic resting, digesting. They’re eating these nutrient dense nourishing foods to impart help with that and support that. It is an amazing thing when you give the body the time it needs and you go upstream and find out what’s causing the problem in the first place, things happen a lot more unimpededly and a lot more effortlessly over time. Yeah, inflammation is linked to many different types of inflammatory problems.
Kimberly: Will, while we’re talking about fertility, I think we focus so much on women, but obviously it affects men and their sperm and their testes.
Will Cole: Yeah, right. Let’s not talk about women now. Oftentimes, you’re right. It’s absolutely. The guys are completely … The guy typically is in such an inflammatory state and it’s the low testosterone. It’s impacting sperm count and sperm health. Yeah, both sides need to be looked at.
How long before you can see benefits with intuitive fasting
Kimberly: Yes. Let’s talk about your new book, Intuitive Fasting in general. Let’s say someone has a particular health goal. They’re trying to get pregnant or they’re just trying to feel better. They had some of the symptoms you talked about a lot, the fogginess and the runny nose and the bloating. I mean, I know this is such a … It’s so hard to make a generalization. But let’s say someone starts to pay attention to the inflammation in their lives, they start to want to reduce it, they start to do some of the fasting. How long have you seen in your clinical research with your patients, how long can you actually start to see benefits?
Will Cole: Wow. If we’re leaning into these aspects, I mean, this goes without saying, but everybody’s coming in at different points of their journey, right? I mean, that’s same with clinically. I’m meeting people that have been dealing with these things for 40 years and for
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